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Pre Implantation Factor (PIF) and Neurogenesis

A possibly astounding discovery has been made by Dr. Eytan Barnea, an OB/GYN researcher and professor at Rutgers. For decades there has been a desire to scientifically explain why the foreign genetic material (the father’s) in a fertilized human egg is not rejected by the mother’s immune system upon attaching itself to the uterus. Researchers have tried mightily to figure out how the mother accomplishes this miraculous task. However, Dr. Barnea cleverly decided to look at what the human embryo could be doing to possible make that happen. There, he discovered the first molecule secreted by a human (or any other mammalian) embryo – a peptide protein molecule he has named Pre-Implantation Factor (PIF).


This molecule, research has shown, goes to over 100 genes in the mother’s body and “synchs” the immune system of the mother and the embryo. This discovery has tremendous potential in the field of reproduction – up to 20% of infertility might be explained by a lack of secreted PIF, in which case no one can ever get pregnant. However, there is more.


PIF has terrific anti-inflammatory properties without general suppression of the immune system. More extraordinary, PIF, being one of the first molecules generated by a tiny embryo, has the property of possible control over adult stem cells. In peer review studies, tissue damaged by inflamation has been healed and repaired by the administration of PIF (in arthritis, MS, and juvenile diabetes).


The good news, for victims of TBI, is that PIF has exhibited properties of neuro-regeneration. In a peer reviewed study, the administration of PIF in mice with spinal cord injury from MS, allowed a large percentage of mice with rear leg paralysis to walk. We know that PIF works in humans, as the beneficial effects during the pregnancy of autoimmune patients is well documented. Human trials are planned to start before the end of 2013. Hopefully, within two to three years, the FDA will approve the use of PIF for at least some purposes, and a great deal of good can be done. (See peer review studies by going to www.pubmed.org and look up the discovery of PIF, Barnea, R. T.)

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